منابع مشابه
Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling
Signaling networks downstream of receptor tyrosine kinases are among the most extensively studied biological networks, but new approaches are needed to elucidate causal relationships between network components and understand how such relationships are influenced by biological context and disease. Here, we investigate the context specificity of signaling networks within a causal conceptual frame...
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Microarray-based sandwich immunoassays can simultaneously detect dozens of proteins. However, their use in quantifying large numbers of proteins is hampered by cross-reactivity and incompatibilities caused by the immunoassays themselves. Sequential multiplex analyte capturing addresses these problems by repeatedly probing the same sample with different sets of antibody-coated, magnetic suspensi...
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Extracellular signaling is commonly mediated through post-translational protein modifications that propagate messages from membrane-bound receptors to ultimately regulate gene expression. Signaling cascades are ubiquitously intertwined, and a full understanding of function can only be gleaned by observing dynamics across multiple key signaling nodes. Importantly, targets within signaling cascad...
متن کاملIdentification of candidate regulators of embryonic stem cell differentiation by comparative phosphoprotein affinity profiling.
Embryonic stem cells are a unique cell population capable both of self-renewal and of differentiation into all tissues in the adult organism. Despite the central importance of these cells, little information is available regarding the intracellular signaling pathways that govern self-renewal or early steps in the differentiation program. Embryonic stem cell growth and differentiation correlates...
متن کاملCerebral Phosphoprotein Promoted by Electrical Impulses
It has been shown (Heald, 1956b) in cerebral slices that duringtherapidbreakdown ofphosphocreatine, brought about by brief passage of electrical pulses (see Heald, 1954), there is an increased exchange of phosphate between the phosphates soluble in trichloroacetic acid and those in the insoluble residue. Thus in cerebral slices which had been allowed to metabolize radioactive inorganic phosphat...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2008
ISSN: 1535-3893,1535-3907
DOI: 10.1021/pr700816k